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EXPERTISE

Driving Innovation Through Science

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Driven by science, our portfolio of essential care products – spanning skin, scalp, oral, inner, and pet health – enhances well-being through innovations in Microbiome Science, Glycoscience, and Encapsulation.
Microbiome Science

Microbiome Science

Our SUPER-METABIOTICS solution is based on a natural co-culture fermentation process that mimics human digestion. This patented green technology enables a substrate to be fermented by dozens of bacterial strains (lactic acid bacteria and bifidobacteria) or by a sophisticated blend of different bacteria/yeast/acetobacters in a single step. The result is a product rich in several hundred identified and characterized active metabolites, acting in synergy on multiple pathways, rather than one single active molecule. In particular, lactic acid bacteria are widespread microorganisms present in any carbohydrate-rich environment. In humans, they are found in various microbiota (notably gastrointestinal and genito-urinary). During the fermentation process, these bacteria produce organic acids, enzymes and other active substances with specific physiological functions. These are known as metabolites. Unlike conventional probiotics that focus on delivering living bacteria, or prebiotics that provide only the nutrients to feed such bacteria, our SUPER-METABIOTICS technology focuses on the production of multiple active metabolites - the biochemical outputs of microbial life that directly contribute to the microbiome and the cells health. Our five-day one-step co-culture process is performed at a temperature of 37°C, with musical vibrations. This patented biomimetic fermentation process enhances and optimizes the production of metabolites by the microorganisms in a reproducible way. The SUPER-METABIOTICS ingredients produced through our technology are rich in up to 500 different metabolites. They optimize human microbial ecosystems, not only in localized areas such as the skin, scalp, intestines, and oral cavity but also systemically, creating a domino effect, resulting in a significant improvement in health, in all parts of the body. Thanks to these SUPER-METABIOTICS, we offer a revolutionary vision of microbiome health. The broad-spectrum synergistic action of the metabolites benefits both cells and tissues, as well as the overall flora, rather than activating specific strains. This holistic approach mirrors natural and human fermentation processes – a synergistic collaboration among multiple microorganisms working in harmony. It fosters connections between microbiomes and revolutionizes the traditional beauty care experience, offering a comprehensive well care. In addition to its efficacy, our SUPER-METABIOTICS technology prioritizes naturalness and sustainability. By leveraging the natural efficiency of our microbial partners, this technology utilizes minimal water and energy. Remarkably, only ten kilograms of substrate is needed to produce one ton of finished product! Its minimal environmental footprint makes this technology an ideal choice for eco-conscious consumers and businesses, aligning with global sustainability goals and fostering a greener future in health and beauty care.

Glycoscience

Glycoscience

Glycoscience is an interdisciplinary field that studies the structure, function, and roles of carbohydrates (i.e., glycans or sugars) in living organisms. Glycans—including monosaccharides, oligosaccharides, polysaccharides, and their complexes—are not only sources of energy, but, due to their structural complexity and diversity, also serve as important “information carriers” in life processes. Capable of encoding vast amounts of biological information, glycans are considered the “third molecular language” after DNA and proteins, playing irreplaceable roles in key life processes such as cell recognition, immune defense, and signal transduction. In the realm of skin health, glycans display intelligent functions on multiple levels. Firstly, polysaccharides are core components for maintaining the structure and function of the skin, providing powerful moisture retention to keep the skin hydrated and elastic. Secondly, biological sugars can precisely regulate physiological activities in the skin through "glycans-lectins" signaling pathways, activating skin regeneration enzyme systems, promoting collagen synthesis, and thereby reducing wrinkles. In addition, Glycoscience has wide applications in skin microecology and immune regulation: small molecule glycans act as prebiotics to promote the growth of beneficial bacteria; large polysaccharides form a barrier on the skin surface to inhibit the colonization of pathogenic bacteria; while glycan complexes can guide the migration of immune cells, accelerating wound healing. By deeply analyzing the multiple functions of glycans, Glycoscience brings innovative solutions for anti-aging, repair, and microecological management of the skin, driving skincare technology towards a new era of precision and efficiency. SETHIC is dedicated to advancing the application of Glycoscience in the field of precision skincare. By utilizing GLYcoPROFILE® platform, we can gain a deeper understanding of the glycan units within plant polysaccharides, as well as their biological activity and skincare efficacy. This provides a scientific foundation for the precise and effective use of polysaccharides in skincare. Based on Glycoscience studies, we have developed the following products: GLYCOWAVE,it’s an innovative anti-aging solution combining glycobiology, gene regulation, and natural polysaccharides, targeting 12 hallmarks of ageing, for rapid, visible results and enhanced skin health. LACTIMO®, a natural oligosaccharide powered by Glycoscience, balances the oral microbiome by targeting odor-causing bacteria, effectively reducing malodor and VSCs with breath-freshening results comparable to CPC, chlorhexidine, and zinc lactate.

Encapsulation

Encapsulation

Advanced Delivery System (ADS) Encapsulation Technology Our Advanced Delivery System (ADS) is a patented cutting-edge liposomal encapsulation technology designed to enhance the stability, solubility, and bioavailability of active compounds. By targeting delivery directly to the cell mitochondria, ADS ensures optimal absorption and maximized antioxidant activity at the cellular level. It protects sensitive compounds from degradation caused by heat, oxidation, and digestion, improving their efficacy. This innovative system also supports water solubility, making it easier to formulate and integrate into various products. By optimizing the delivery process, ADS technology amplifies the health benefits of natural ingredients, setting a new standard in nutrient delivery science. Our key innovation, VIQUA®, is powered by the patented ADS advanced delivery system, which delivers the potent polyphenols of Royal Rubis pomegranates directly to the mitochondria. This technology ensures 100% water solubility, superior stability, and proven efficacy in promoting radiant skin, reducing signs of aging, protecting against UV damage, and alleviating PMS symptoms. CycloXome™ Technology At the heart of our innovation is CycloXome™ Technology, a cutting-edge encapsulation system powered by beta-cyclodextrin. This advanced technology leverages the unique molecular structure of cyclodextrins, which form hydrophobic cavities capable of encapsulating nonpolar molecules. The encapsulated "guest" molecules are securely held within the cyclodextrin "host" through van der Waals forces, creating a stable and protective environment for active ingredients. The encapsulated active ingredients are shielded from degradation, ensuring their stability and potency over time. CycloXome™ technology enables the gradual release of actives in response to changes in physico-chemical conditions. Due to the hydrophilic nature of cyclodextrin, it cannot penetrate the skin barrier. Actives are released precisely at the skin's surface, ensuring targeted efficacy. Based on CycloXome™ technology, CAFFENERGY® 50C is a unique active containing 50% caffeine encapsulated in cyclodextrin. Produced without the use of solvents, CAFFENERGY® 50C offers multiple advantages over free caffeine, including higher bioavailability, better solubility, no cytotoxicity, full regulatory and proven efficacy to promote blood microcirculation, reduce eyebags and anti-hair loss.

Contact us to discuss how our solutions can help you achieve your goals.

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JAPAN WELLCARE INNOVATION CENTER

Shintomi HJ bldg 5F1-12-7, Shintomi-Cho, Chuo-ku, Tokyo 104-0041, JAPAN

CHINA MAIN OFFICE

R&F Center, Office 3904, 10 Huaxia Road, Zhujiang New Town, Tianhe District, 510623 Guangzhou, CHINA

HONGKONG HEADQUARTERS

King Palace Plaza, Unit C, 8/F, No. 55 King Yip Street, Kwun Tong, Kowloon, HONG KONG SAR

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